Episode 104 | AI & Automation Unlocking Materials Discovery | Joseph Krause

In this episode of Machine Minds, I sit down with Joseph Krause, co-founder and CEO of Radical AI.

We talk about Joseph’s path from Rice University and the Army National Guard to building Radical AI. He explains how AI and self-driving labs can speed up materials discovery, why failed experiments are critical data, and where this will first change the world, across aerospace, defense, semiconductors, and energy.

Key topics:

  • The founding story of Radical AI

  • How AI + autonomous labs form a “materials flywheel”

  • Why negative results matter in science

  • Culture and hiring at Radical AI

  • Working with the White House on the 2025 National AI & R&D Strategy

  • Where early real-world impact will show up

Episode Highlights:

00:00 Machine Minds Show Introduction

03:41 Material class that will fundamentally change humanity

09:28 Commercial Real Estate

16:22 Generation engine AI driven

23:20 Monumental change in the way we do scientific discovery

30:40 Reusable and be able to bring anything

39:46 How do we get closer to our northstar of removing materials

47:51 National AI and R&D Strategy

54:05 Radical AI’s Impact first in the world

Where to Find the Guest:

Connect Joseph Krause on LinkedIn: https://www.linkedin.com/in/josephfkrause/

Connect Joseph Krause on X: https://x.com/josephfkrause?lang=en

Connect Radical AI on LinkedIn: https://www.linkedin.com/company/radicalai/

Company Website: https://www.linkedin.com/company/radicalai/

Radical AI is hiring! View open roles at: https://jobs.lever.co/RadicalAI

Machine Minds:

Samson Rose: https://samsonrose.com/

Apple Podcast: https://podcasts.apple.com/us/podcast/machine-minds/id1697983733‍

Google Podcast: https://podcasts.google.com/feed/aHR0

Let’s Connect on Social Media:

Instagram: https://www.instagram.com/machinemindsshow/

LinkedIn: https://www.linkedin.com/in/gregtoroosian/

Facebook: https://www.facebook.com/machinemindsshow/

YouTube: https://www.youtube.com/@machinemindsshow

Spotify: https://open.spotify.com/show/1apGh7x..‍

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Episode 105 | Inside the Mind of a Growth-Stage Investor | Manas Punhani

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Episode 103 | Inside The Defense VC Boom | Nick Snoad